Some aspects of vitamin E related to humans and breast cancer prevention
Abstract
The biological activities of vitamin E are related to the cellular functions and presence of sufficient tissue concentrations of this micronutrient.
Most of the stored vitamin E is in the adipose tissue where it appears to be distributed equally.
The breast adipose tissue has similar vitamin E concentrations as other parts of the body. The ductal systems also store vitamin E in sufficient concentrations to maintain cellular functions. The milk secreted from the ducts of the breast contains a high concentration of tocopherol.
Whereas the normal breast tissue presumably utilizes vitamin E as an antioxidant, tumor tissue appears to handle vitamin E differently.
Breast tumors possessing estrogen negative receptors and having poor histological differentiation have lower concentrations of vitamin E than tumors with positive estrogen receptors and well differentiated histology.
Since vitamin E is considered the principal, if not sole, chain-breaking lipophilic antioxidant in plasma and tissue, its role as a potential chemopreventive agent in breast cancer should be further investigated.
The combination of vitamin E with other cancer chemopreventive agents appears to be a reasonable procedure.
See also:
- Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy;
- The Di Bella Method (A Fixed Part - Alpha tocopheryl acetate/Vitamin E);
- The Di Bella Method (A Fixed Part - All-Trans Retinoic Acid);
- All-Trans-Retinoic Acid (ATRA - analogues and/or derivatives);
- Complete objective response to biological therapy of plurifocal breast carcinoma.