Time-dependent influence of the somatostatin analogue octreotide on the proliferation of rat astrocytes and glioma cells
Published on Monday, 30 November -0001
Abstract
The somatostatin receptor subtype sst2 was visualized by immunostaining on cultivated rat astrocytes and C6 rat glioma cells.
Octreotide, a metabolically stable sst2 agonist reduced [3H]thymidine incorporation into DNA of both cell types dose-dependently only after short-time application (2-5 h), after prolonged incubation (> 12 h) no antiproliferative effect was measurable.
We conclude that sst2 receptors may be desensitized. Thus, desensitization might hinder application of octreotide to reduce glial tumour growth.