Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer
Published on Tuesday, 12 January 2016
Abstract
We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney.
Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR.
Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p < .01).
This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas.
These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.