The Safety of High-Dose Vitamin E Supplementation in Healthy Japanese Male Adults
Abstract
we administered high-dose vitamin E to healthy adult male volunteers and assessed the safety of such supplementation.
Fourteen volunteers received daily 1, 200 IU of vitamin E (800mg of D-α-tocopherol) for 28 d and eight controls were also enrolled.
The volunteers treated with vitamin E showed no abnormalities during the study period.
The α-tocopherol concentrations of plasma and platelets were markedly elevated by vitamin E treatment, but there were no significant differences in platelet aggregation, coagulation, and the clinical parameters between the two groups.
In conclusion, a high dose of vitamin E for 28 d had no adverse effects in healthy men.
See also:
- The Di Bella Method (A Fixed Part - Alpha tocopheryl acetate/Vitamin E);
- Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy;
- All-Trans-Retinoic Acid (ATRA - analogues and/or derivatives);
- The Di Bella Method (A Fixed Part - Vitamin C/Ascorbic Acid, 2–4 grams per day, orally).