Salivary Levels Vitamin E and C in Different Histological Grading of Oral Cancer

Abstract

Objective: To asses the salivary levels of vitamin C and vitamin E in patients with different histological grading of oral cancer.

Methods: Antioxidant vitamin E and C levels were estimated in 15 patients of oral cancer grade II, 10 patients of grade III and 12 patients of grade IV. These tumors were classified according to UICC criteria. Unstimulated whole saliva from subjects was collected over ice and samples were centrifuged and frozen at –20°C until analysis. Vitamin C and vitamin E were estimated by HPLC tecnique. All procedures were performed under light protected conditions. Data was analyzed by SPSS (7.0), and student t-test were applied.

Results: The salivary levels of vitamin C e E were significantly decreased in patients with advancing histological grade of oral cancer (p<0.001). There was a significant positive correlation between redution in vitamin C and vitamin E (r=2.104, p<0.001).

Conclusion: Antioxidant nutrients may be utilized to a greater extent in oral cancer patient to counteract free radical mediated cell disturbances, resulting in a reduction in salivary antioxidantlevels.

 

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See also:

- Official Web Site: The Di Bella Method;

- The Di Bella Method (A Fixed Part - Alpha tocopheryl acetate/Vitamin E, approximately 20 grams per day orally);

- Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy;

- All-Trans-Retinoic Acid (ATRA - analogues and/or derivatives) - In vitro, review and in vivo publications;

- The Di Bella Method (A Fixed Part - All-Trans Retinoic Acid, Analogues and/or Derivatives - Approximately 60mg per day orally: 40mg per day Beta-Carotene/β-Carotene, 10mg per day ATRA and 10mg per day Axerophthol palmitate);

- The Di Bella Method DBM improved survival objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck.