Physiologic Effect of all Trans Retinoic Acid (Atra) on Vital Organ Damage and Lipid Profile in Benzo (a) Pyrene Induced Lung Metastasis
Abstract
All-trans retinoic acid (ATRA), an active metabolite of retinal, has been shown to exert anti-cancer activities in a number of types of cancer cells and tissues.
In the present study, we have investigated the effect of ATRA on the physiologic changes normally observed in cancer patient during or after development of cancer.
The parameters analysed are lung/liver tissue damage markers in serum, lipid profile in serum and the histologic changes in lung and liver during benzo(a)pyrene induced lung cancer development in BALB/c mice.
Benzo(a)pyrene (50 mg/kg wt) induced lung cancer animals showed abnormal changes in the serum lipids, lipoproteins and marker enzymes such as gamma glutamyl transpeptidase and lactate dehydrogenase. An extensive lung/liver histologic change was also observed.
Treatment with ATRA (0.585mg/kg body wt) remarkably reverted all the above alterations, which indicates the anticancer effect that was further confirmed by histopathological analysis.
Overall, the above data shows that the anticancer effect of ATRA is more pronounced when used as an chemoprotective agent against B(a)P induced lung carcinogenesis.
See also All-Trans-Retinoic Acid (ATRA - analogues and/or derivatives).