Abstract
Vitamin D is a fat soluble vitamin that plays a role in calcium and phosphorus homeostasis.
Recently, extensive research on its extraskeletal actions has linked vitamin D deficiency to an increased risk of infection, diabetes mellitus types 1 and 2, cardiovascular disease, obesity, asthma, inflammatory bowel disease, colon, breast, prostate and ovarian cancer and some neurological diseases.
There are various mechanisms by which vitamin D influences the natural history of cancer. These include the role of vitamin D in the induction of apoptosis, stimulation of cell differentiation, anti-inflammatory and antiproliferative effects and inhibition of angiogenesis, invasion and metastasis.
The aim of this review is to clarify the true role of vitamin D in the onset of breast cancer and evolution of the disease after treatment.
A further aim is to suggest new research directions to identify indications and requirements for vitamin D supplementation in patients with breast cancer.
See also:
- Vitamin D (analogues and/or derivatives) and cancer;
- The Di Bella Method (A Fixed Part - Dihydrotachysterol, Alfacalcidol, synthetic Vitamin D3);
- The Di Bella Method (A Fixed Part - Cyclophosphamide and/or Hydroxyurea tablets, one or two per day);
- Complete objective response to biological therapy of plurifocal breast carcinoma.