Renal Neuroendocrine Neoplasms: A Single-center Experience

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Published on Wednesday, 22 January 2020

Abstract

BACKGROUND: Primary neuroendocrine neoplasms (NENs) of the kidney are exceedingly rare malignancies and the available data are very limited. The natural history and response to treatments have not been well characterized. We have described the presenting features, demographic data, tumor characteristics, and treatment outcomes of patients with renal NENs.

PATIENTS AND METHODS: We performed a retrospective analysis of the data from all Mayo Clinic patients with a tissue diagnosis of a primary renal NEN. The baseline patient and surgical pathologic features and treatment modalities were collected. The time to recurrence after resection and overall survival (OS) were estimated using survival analysis. The Surveillance, Epidemiology, and End Results data were used to estimate the population-wide incidence and OS.

RESULTS: A total of 17 patients were included in the present study, with a median follow-up of 62.8 months. Distant metastasis was present in 29% at diagnosis, with 76% experiencing distant metastasis at any point; 24% had a horseshoe kidney. Of the 17 patients, 14 had undergone surgical resection with no evidence of disease postoperatively. Ten of these patients had documented recurrence. The median time to recurrence was 18 months (95% confidence interval, 9-46 months). Only 1 of the 10 patients showed a radiographic response to systemic therapy. Of 9 patients, 4 had had stable disease with somatostatin analogs. The median OS was 143 months (95% confidence interval, 50-143 months).

CONCLUSIONS: Renal NENs are rare malignancies affecting mostly middle-age patients, with distant metastasis common. Approximately one half of patients will experience stable disease with somatostatin analogs. The OS will usually be > 5 years.

 

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- Official Web Site: The Di Bella Method;

- The Di Bella Method (A Fixed Part - Somatostatin, Octreotide, Sandostatin LAR, analogues and/or derivatives);

- Somatostatin in oncology, the overlooked evidences - In vitro, review and in vivo publications;

- Publication, 2018 Jul: Over-Expression of GH/GHR in Breast Cancer and Oncosuppressor Role of Somatostatin as a Physiological Inhibitor (from Di Bella's Foundation);

- Publication, 2018 Sep: The over-expression of GH/GHR in tumour tissues with respect to healthy ones confirms its oncogenic role and the consequent oncosuppressor role of its physiological inhibitor, somatostatin: a review of the literature (from Di Bella's Foundation);

- Publication, 2019 Aug: The Entrapment of Somatostatin in a Lipid Formulation: Retarded Release and Free Radical Reactivity (from Di Bella's Foundation);

- Publication, 2019 Sep: Effects of Somatostatin and Vitamin C on the Fatty Acid Profile of Breast Cancer Cell Membranes (from Di Bella's Foundation);

- The Di Bella Method (A Fixed Part - Bromocriptine and/or Cabergoline);

- The Di Bella Method (A Fixed Part - Cyclophosphamide 50mg tablets and/or Hydroxyurea 500mg tablets, one or two per day);

- Pancreatic Adenocarcinoma: clinical records on 17 patients treated with Di Bella's Method;

- The Di Bella Method Increases by the 30% the survival rate for Pancreas tumors and for this reason should be proposed as first line therapy for this type of cancer;

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