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Vitamin D and Non-Hodgkin Lymphoma Risk in Adults: A Review
Published on Tuesday, 15 September 2015
Abstract
Animal and human studies support a protective effect of Vitamin D sufficiency related to malignancy by uncovering paracrine and autocrine effects of extra-renal 25(OH)D activation including: regulation of cell cycle proliferation, apoptosis induction, and increased cell differentiation signaling.
Recent epidemiologic studies demonstrate a reduction in non-Hodgkin lymphoma (NHL) risk with increased sunlight exposure.
As sunlight is a major vitamin D source, it has been suggested that vitamin D status may mediate this observed association.
This review provides a comprehensive discussion of the current epidemiologic evidence with regard to the investigation of an association between vitamin D status and NHL risk.
See also Vitamin D and cancer.
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