Medullary thyroid carcinoma (MTC) treated with 177Lu-DOTATATE PRRT: a report of two cases

Abstract

Two patients diagnosed with metastatic medullary thyroid carcinoma (MTC) were referred for peptide receptor radionuclide therapy (PRRT) with Lu-[DOTA,Tyr]octreotate (DOTATATE).

Each patient was treated with 4 doses of Lu-DOTATATE given 2 months apart.

One patient achieved stable disease for 10 months then chose to pursue surgery, and the other achieved stable disease for 9 months on imaging; however, calcitonin continued to rise.

The use of Lu-DOTATATE PRRT therapy in the management of MTC warrants further research.

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