Differential binding to soluble nuclear receptors and effects on cell viability of retinol and retinoic acid in cultured retinoblastoma cells

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Published on Wednesday, 10 May 2017

Abstract

Human retinoblastoma cells in culture contain soluble receptors for both 3H-retinol and 3H-retinoic acid which are separate and distinct as assessed by specificity, enzyme susceptibility and binding affinity.

Total cellular binding of retinol correlates well with its rapid effect on cell mortality.

A limited number of soluble nuclear receptor sites for 3H-retinoic acid but not 3H-retinol are observed after incubation of the 3H-retinoid with intact cells indicating a possible preferential effect of retinoic acid at the gene level.

 

 

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See also:

- All-Trans-Retinoic Acid (ATRA - analogues and/or derivatives);

- Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy.