Effect of prolactin on the prostate

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Published on Tuesday, 26 December 2017

Abstract

We propose that:

1. Prolactin is a trophic hormone required for normal development and growth of prostate as well as other tissues;

2. Citrate production, the major function of prostate, is directly regulated by prolactin;

3. The mechanisms of prolactin regulation of citrate production by prostate epithelial cells include;

3a. Regulation of the pmAAT gene, which results in an increase in the biosynthesis of mAAT and, ultimately, an increase in citrate synthesis (the prolactin regulation of gene transcription is mediated via PKC);

3b. Inhibition of citrate oxidation, possibly via zinc inhibition of m-aconitase;

3c. Stimulation of aspartate transport, possibly via regulation of the biosynthesis of the high-affinity aspartate transporter;

4. These relationships apply to normal human prostate, and might have important implications in the pathogenesis of prostate neoplasms;

5. The regulation of prostate citrate production is the reproductive function of prolactin in males.

 

 

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See also:

- The Di Bella Method (A Fixed Part);

- The Di Bella Method (DBM) in the treatment of prostate cancer: a preliminary retrospective study of 16 patients and a review of the literature;

- Cyclophosphamide plus Somatostatin, Bromocriptin, Retinoids, Melatonin and ACTH in the Treatment of Low-grade Non-Hodgkin’s Lymphomas at Advanced Stage: Results of a Phase II Trial;

- Relapse of High-Grade Non-Hodgkin’s Lymphoma After Autologous Stem Cell Transplantation: A Case Successfully Treated With Cyclophosphamide Plus Somatostatin, Bromocriptine, Melatonin, Retinoids, and ACTH;

- Low-grade Non-Hodgkin Lymphoma at Advanced Stage: A Case Successfully Treated With Cyclophosphamide Plus Somatostatin, Bromocriptine, Retinoids, and Melatonin;

- The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 55 cases of Lymphomas;

- Large B-cells Non-Hodgkin's Lymphoma, Stage IV-AE: a Case Report;

- Non-Hodgkin's Lymphoma, Stage III-B-E: a Case Report.