Decrease in vitamin E levels in the bone marrow of mice receiving whole-body X-ray irradiation

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Published on Wednesday, 04 September 2019

Abstract

Mice were subjected to whole-body x-ray irradiation, and changes in vitamin E content and lipid peroxide levels in various tissues were examined.

When mice were irradiated with 6 Gy, vitamin E content (per mg protein) in the bone marrow began to decrease 3 h later and a marked decrease to the level of 30% of that of the controls was observed on day 2. Concomitant with the decrease of vitamin E, an increase of lipid peroxide levels was also observed in the bone marrow.

On day 2 after an exposure to doses ranging from 1 to 10 Gy, a dose-dependent decrease of vitamin E and an increase of lipid peroxide levels were observed in the bone marrow with a dose of 3 Gy or more. In contrast, neither a decrease of vitamin E nor an increase of lipid peroxide levels was observed in the liver, kidney, spleen, and testes even with an exposure of up to 10 Gy. After the irradiation, glutathione in the bone marrow decreased, while that in the liver increased.

These results suggest that the bone marrow is more highly susceptible to oxidative damage induced by radiation than other tissues.

 

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See also:

- Official Web Site: The Di Bella Method;

- The Di Bella Method (A Fixed Part - Alpha tocopheryl acetate/Vitamin E, approximately 20 grams per day orally);

- Cancer and Vitamin E (analogues and/or derivatives) and cancer - In vitro, review and in vivo publications;

- Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy;

- The Di Bella Method (A Fixed Part - All-Trans Retinoic Acid, Analogues and/or Derivatives - Approximately 60mg per day orally: 40mg per day Beta-Carotene/β-Carotene, 10mg per day ATRA and 10mg per day Axerophthol palmitate);

- All-Trans-Retinoic Acid (ATRA - analogues and/or derivatives) - In vitro, review and in vivo publications;

- The Di Bella Method (A Variable Part - Omega 3 Essential/Unsaturated Fatty Acids. From 1.5 grams up to 3.0 grams per day orally);

- Beta-Carotene or β-carotene in Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy;

- The Di Bella Method (A Fixed Part - Cyclophosphamide 50mg tablets and/or Hydroxyurea 500mg tablets, one or two per day);

- The Synergism of Somatostatin, Melatonin, Vitamins Prolactin and Estrogen Inhibitors Increased Survival, Objective Response and Performance Status In 297 Cases of Breast Cancer;

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- The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 122 cases of breast cancer;

- Complete objective response to biological therapy of plurifocal breast carcinoma;

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