Vitamin D3 analogue (EB 1089) inhibits in vitro cellular proliferation of human colon cancer cells

Abstract

The active form of vitamin D3, namely 1,25-dihydroxy- vitamin D3, has been shown to inhibit the proliferation of some tumour cells.

The use of vitamin D3 as an antiproliferative agent in the treatment of cancer is limited, however, by its hypercalcaemic effects.

Synthetic analogues of vitamin D3 have been developed which retain cellular differentiation and growth inhibitory activities but with reduced calcaemic activity.

Recently, several analogues of 1,25-dihydroxyvitamin D3 have been shown to be potent antiproliferative agents in colon cancer cells.

The effects of the vitamin D3 analogue EB 1089 in three previously untested colon cancer cell lines arc reported here.

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See also Vitamin D and cancer.