Insulin-like growth factor-1 is essential to the increased mortality caused by excess growth hormone: a case of thyroid cancer and non-Hodgkin's lymphoma in a patient with pituitary acromegaly

Published on Tuesday, 07 July 2015


The effects of growth hormone are mediated in part by stimulating the production of insulin-like growth factor-1.

Insulin-like growth factor-1 has significant effects on cell proliferation and differentiation, it is a potent mitogen, and it is a powerful inhibitor of programmed cell death (apoptosis).

Insulin-like growth factor-1 also has a well-established role in the transformation of normal cells to malignant cells.

Case reports on a possible association between elevated growth hormone and cancer risk in a variety of patient groups have been published.

Here, we describe clinical and laboratory findings for a patient with acromegaly who first developed thyroid cancer, and then, in the follow up period, probably due to poorly controlled insulin-like growth factor-1 levels, developed a large cell non-Hodgkin's lymphoma.

A search revealed that a case with these peculiarities had not previously been reported.



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