Melatonin in Protection against Oxidative Damage Caused by Potential Carcinogens

Abstract

Oxidative stress participates in the complex process of carcinogenesis. Any carcinogen may initiate the process of cancer development by generating free radicals. Numerous indicators of oxidative damage are enhanced in result of this carcinogenic action.

Melatonin (N-acetyl-5-methoxytryptamine), an antioxidant and free radical scavenger, can potentially protect against oxidative damage and cancer initiation.

Indeed, in numerous studies, examining several parameters of oxidative damage and using a number in vitro and in vivo models, this indoleamine has been shown to protect DNA and cellular membranes from carcinogen-induced oxidative abuse.

The protection, provided by melatonin against cellular damage, due to carcinogens, makes it a potential therapeutic supplement in conditions of increased cancer risk.

Taken from the Book: Melatonin: Biological Basis of its Function in Health and Disease, Chapter 21.

See also About Melatonin.