Vitamin D and the immune system: new perspectives on an old theme

Abstract

It is almost 30 years since an interaction between vitamin D and the immune system was first documented.

Although this was initially proposed as a nonclassic effect of vitamin D associated with granulomatous diseases, our current view is now changed considerably.

Recent studies have shown a potential physiologic role for vitamin D in regulating normal innate and adaptive immunity.

Future studies now need to focus on the clinical implications of vitamin D–mediated immunity and, in particular, the possible beneficial effects of supplementary vitamin D with respect to infectious and autoimmune diseases.

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See also Vitamin D and cancer.