Melatonin: does it have utility in the treatment of hematologic neoplasms?

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Published on Friday, 08 September 2017

Abstract

Melatonin, discovered in 1958 in the bovine pineal tissue, is an indoleamine that modulates circadian rhythms and has a wide variety of other functions.

Hematologic neoplasms are the leading cause of death in children and adolescents throughout the world.

Research has demonstrated that melatonin is a low-toxicity protective molecule against experimental hematological neoplasms, but the mechanisms remain poorly defined.

Herein, we provide an introduction to hematologic neoplasms and melatonin, especially as they relate to the actions of melatonin on hematologic carcinogenesis.

Secondly, we summarize what is known about the mechanisms of action of melatonin in the hematological system, including its proapoptotic, pro-oxidative, anti-proliferative, and immunomodulatory actions.

Thirdly, we discuss the advantages of melatonin in combination with anti-hematological malignancy drugs, as well as its other benefits on the hematological system.

Finally, we summarize the findings that are contrary to the suppressive effects of melatonin on cancers of hematological origin.

It is the hope of the authors that this information will be helpful in the design of studies related to the therapeutic efficacy of melatonin in hematological neoplasms.

 

NOTE: This publication cites The Di Bella Method (DBM) in these pubblications:

 

 

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